解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Disulfide bonds stabilize the tertiary- and quaternary structure of proteins. In addition, they can be used to engineer redox-sensitive (bio)materials and drug-delivery systems. Many of these applications require control of the stability of the disulfide bond. It has recently been shown that the charged microenvironme...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400501c
更新日期:2013-07-08 00:00:00
abstract::Minimally invasive implants and/or scaffolds integrated with multiple functionalities are of interest in the clinical settings. In this paper, chitosan (CTS) functionalized poly(lactic-co-glycolic acid) (PLGA) microspheres containing a model payload, lysozyme (Lyz), were prepared by a water-in-oil-in-water emulsion me...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm4003464
更新日期:2013-06-10 00:00:00
abstract::The formation of amylose-polystyrene inclusion complexes via a novel two-step approach is described. In the first-step, styrene was inserted inside the amylose helical cavity, followed by free radical polymerization in the second step. The inclusion complexes were characterized by attenuated total reflection fourier t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400340k
更新日期:2013-06-10 00:00:00
abstract::A series of well-defined thermoresponsive diblock copolymers (PEO45-b-PtNEAn, n=22, 44, 63, 91, 172) were prepared by the atom transfer radical polymerization of trans-N-(2-ethoxy-1,3-dioxan-5-yl) acrylamide (tNEA) using a poly(ethylene oxide) (PEO45) macroinitiator. All copolymers are water-soluble at low temperature...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400180n
更新日期:2013-05-13 00:00:00
abstract::These studies illustrate synthetic paths to covalently attach T1 and Φ11 bacteriophages (phages) to inert polymeric surfaces while maintaining the bacteriophage's biological activities capable of killing deadly human pathogens. The first step involved the formation of acid (COOH) groups on polyethylene (PE) and polyte...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400290u
更新日期:2013-05-13 00:00:00
abstract::A strategy to light-trigger ionic cross-linking of alginates by incorporating a photosensitive Ca2+ cage (nitr-T) is presented. Upon irradiation, free Ca2+ was released, and this caused gelation of the alginate solution. Addition of Ca2+ "on-demand" allowed us to obtain homogeneous alginate (ALG) gels using concentrat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400022h
更新日期:2013-05-13 00:00:00
abstract::Antibacterial nanodevices could bring coatings of plastic materials and wound dressings a big step forward if the release of the antibacterial agents could be triggered by the presence of the bacteria themselves. Here, we show that novel hyaluronic acid (HA)-based nanocapsules containing the antimicrobial agent polyhe...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm302003m
更新日期:2013-04-08 00:00:00
abstract::A multiple targeted drug carrying bilayer membrane for preventing an abdominal adhesion is prepared by electrospinning. Two bioactive drugs were successfully incorporated into this bilayer membrane and can be independently released from nanofibrous scaffolds without losing structural integrity and functionality of the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301997e
更新日期:2013-04-08 00:00:00
abstract::Hydrogel scaffolds are used in biomedicine to study cell differentiation and tissue evolution, where it is critical to control the delivery of chemical cues both spatially and temporally. While large molecules can be physically entrapped in a hydrogel, moderate molecular weight therapeutics must be tethered to the hyd...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400169d
更新日期:2013-04-08 00:00:00
abstract::In situ forming reduction-sensitive degradable nanogels were designed and developed based on poly(ethylene glycol)-b-poly(2-(hydroxyethyl) methacrylate-co-acryloyl carbonate) (PEG-P(HEMA-co-AC)) block copolymers for efficient loading as well as triggered intracellular release of proteins. PEG-P(HEMA-co-AC) copolymers ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400206m
更新日期:2013-04-08 00:00:00
abstract::The purpose of this study was to gain mechanistic insights into the effect of different formulation parameters on the degradation and release behavior of protein-loaded nanoparticulate carrier systems based on an aliphatic polyester with pendant hydroxyl groups, poly(lactic-co-glycolic-hydroxymethyl glycolic acid) (pL...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301900t
更新日期:2013-04-08 00:00:00
abstract::The purpose of this study is to investigate the combined effects of oxygen plasma treatments and silver nanoparticles (Ag) on PLGA in order to modulate the surface antimicrobial properties through tunable bacteria adhesion mechanisms. PLGA nanocomposite films, produced by solvent casting with 1 wt % and 7 wt % of Ag n...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301524e
更新日期:2013-03-11 00:00:00
abstract::There is compelling evidence that, beyond their traditional role in hemostasis and thrombosis, platelets play a significant role in mediating hematologic mechanisms of tumor metastasis by directly and indirectly interacting with pro-metastatic cancer cells. With this rationale, we hypothesized that platelets can be an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301996p
更新日期:2013-03-11 00:00:00
abstract::Herein, we developed a new gene delivery vector by grafting a betaine monomer (N,N-dimethyl(acrylamidopropyl)ammonium propane sulfonate, DMAAPS) onto 25 KDa polyethylenimine (PEI 25K) via the Michael addition reaction. The graft ratio for betaine on PEI polymer could be readily controlled, and in this study three PEI-...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301826m
更新日期:2013-03-11 00:00:00
abstract::Cationic spherical polyelectrolyte brushes (SPBs) were synthesized by photoemulsion polymerization, consisting of a polystyrene core with a diameter around 80 nm and a poly(2-aminoethylmethacrylate hydrochloride) (PAEMH) shell with a thickness from 10 to 50 nm densely grafted on the core surface. The binding of variou...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301865g
更新日期:2013-03-11 00:00:00
abstract::PLGA nanoparticles are among the most studied polymer nanoformulations for several drugs against different kinds of malignant diseases, thanks to their in vivo stability and tumor localization exploiting the well-documented "enhanced permeation and retention" (EPR) effect. In this paper, we have developed uniform curc...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm3017324
更新日期:2013-03-11 00:00:00
abstract::To develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excel...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301720g
更新日期:2013-02-11 00:00:00
abstract::Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well a...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301598g
更新日期:2013-02-11 00:00:00
abstract::meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can be used in photodynamic therapy (PDT) to induce cell death through generation of reactive oxygen species in targeted tumor cells. However, TMP is highly hydrophilic, and therefore, its ability to accumulate intracellularly is li...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301858a
更新日期:2013-02-11 00:00:00
abstract::This study investigated the impact of the protein adsorption mechanism(s) on the efficiency of thermally controlled cell adhesion and release from poly(N-isopropyl acrylamide) brushes. Large format polymer gradients were used to screen for grafting densities and substrate chemistries that alter both cell adhesion at 3...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301390q
更新日期:2013-01-14 00:00:00
abstract::Imbalanced homeostasis and oligomerization of the amyloid-β (Aβ) peptide in the brain are hallmarks of Alzheimer's disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing Aβ from the brain or inducing inflammation. Recent evidence suggests that clearance of Aβ by microglia...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301401b
更新日期:2013-01-14 00:00:00
abstract::Dragline silk from orb-weaving spiders is a copolymer of two large proteins, major ampullate spidroin 1 (MaSp1) and 2 (MaSp2). The ratio of these proteins is known to have a large variation across different species of orb-weaving spiders. NMR results from gland material of two different species of spiders, N. clavipe...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301110s
更新日期:2012-12-10 00:00:00
abstract::Single-molecule total internal reflection fluorescence microscopy was used to observe the dynamic behavior of polycytosine single-stranded DNA (ssDNA) (1-50 nucleotides long) at the interface between aqueous solution and hydrophilic (oligoethylene glycol-modified fused silica, OEG) and hydrophobic (octadecyltriethoxys...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301289n
更新日期:2012-12-10 00:00:00
abstract::In this study, an novel amphiphilic block copolymer P[PEGMA-b-(DEMA-co-APMA)]-FA and its cross-linker uracil-(CH2)6-uracil (U-(CH2)6-U) were synthesized and used as the targeted and pH-responsive nanocarriers for anticancer drug delivery. The hydrophobic block of the copolymer contains adenine (A) and tertiary amine m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301424r
更新日期:2012-12-10 00:00:00
abstract::We study the fibrillation pathway of ovalbumin protein and report the simultaneous formation of several types of fibrils, with clear structural and physical differences. We compare the fibrillation mechanisms at low pH with and without salt, and follow the kinetics of fibrils growth by atomic force microscopy (AFM), s...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301481v
更新日期:2012-12-10 00:00:00
abstract::In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301453g
更新日期:2012-12-10 00:00:00
abstract::A novel, two-layer hierarchical architecture based on surface-initiated atom transfer radical polymerization was investigated. It combines a thin and highly dense first layer, for nonfouling properties, with a loose second layer for high immobilization levels of active biomolecules. Sodium azide treatment, to reduce t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301335r
更新日期:2012-12-10 00:00:00
abstract::Poly((N-vinylpyrrolidone)-block-poly(vinyl acetate)) (PVP-b-PVAc) block copolymers of varying molecular weight and hydrophobic block lengths were synthesized via controlled radical polymerization and investigated as carriers for the solubilization of highly hydrophobic riminophenazine compounds. These compounds have r...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301410d
更新日期:2012-12-10 00:00:00
abstract::This paper introduces a chitosan microneedle patch for efficient and sustained transdermal delivery of hydrophilic macromolecules. Chitosan microneedles have sufficient mechanical strength to be inserted in vitro into porcine skin at approximately 250 μm in depth and in vivo into rat skin at approximately 200 μm in de...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301293d
更新日期:2012-12-10 00:00:00
abstract::Chimeric DNA containing parallel (ps) and antiparallel (aps) duplex elements as well as poly-dC tracts were designed and synthesized. Oligonucleotide duplexes with ps chain orientation containing reverse Watson-Crick dA-dT base pairs and short d(C)2 tails are stabilized under slightly acidic conditions by hemiprotonat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301471d
更新日期:2012-12-10 00:00:00
abstract::Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB2/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an e...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301384y
更新日期:2012-12-10 00:00:00
abstract::Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could b...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301441x
更新日期:2012-12-10 00:00:00
abstract::We have investigated the self-assembly of fluorenylmethoxycarbonyl-conjugated dialanine (Fmoc-AA) molecules using combined computational and experimental approaches. Fmoc-AA gels were characterized using transmission electron microscopy (TEM), circular dichroism (CD), Fourier transform infrared (FTIR), and wide-angle ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301007r
更新日期:2012-11-12 00:00:00
abstract::For developing broader application of biobased polymers, graft copolymers and comb polymers having poly(lactic acid) (PLA) side chains have been synthesized by using a macromonomer technique. PLA macromonomers (MMm) having a methacryloyl polymerizable group with different PLA chain length with an average length m = 4,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301212a
更新日期:2012-11-12 00:00:00
abstract::Modular proteins have emerged as powerful tools in tissue engineering because both the mechanical and biochemical properties can be precisely controlled through amino acid sequence. Resilin is an attractive candidate for use in modular proteins because it is well-known for having low stiffness, high fatigue lifetime, ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301129b
更新日期:2012-11-12 00:00:00
abstract::We report a facile method of generating ultradense poly(l-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) surface by using high temperature alone, which in turn provides dramatic improvement in resisting nonspecific bioadsorption. X-ray photoelectron spectroscopy (XPS) revealed that the surface graft density increased...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301125g
更新日期:2012-11-12 00:00:00
abstract::The helical coiled coil is a well-studied folding motif that can be used for the design of nanometer-sized bioinspired fibrous structures with potential applications as functional materials. A two-component system of coiled coil based model peptides is investigated, which forms, under acidic conditions, uniform, hundr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300882d
更新日期:2012-11-12 00:00:00
abstract::Forisomes are protein polymers found in leguminous plants that have the remarkable ability to undergo reversible "muscle-like" contractions in the presence of divalent cations and in extreme pH environments. To gain insight into the molecular basis of forisome structure and assembly, we used confocal laser scanning mi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm3008499
更新日期:2012-10-08 00:00:00
abstract::The synthesis of quaternary ammonium (QA)-functionalized silica nanoparticles with and without nitric oxide (NO) release capabilities is described. Glycidyltrialkylammonium chlorides of varied alkyl chain lengths (i.e., methyl, butyl, octyl, and dodecyl) were tethered to the surface of amine-containing silica nanopart...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301108x
更新日期:2012-10-08 00:00:00
abstract::Herein we report the synthesis of biodegradable hyperbranched polyglycerols (BHPGs) having acid-cleavable core structure by anionic ring-opening multibranching polymerization (ROMBP) of glycidol using initiators bearing dimethyl and cyclohexyl ketal groups. Five different multifunctional initiators carrying one to fou...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300959h
更新日期:2012-10-08 00:00:00